Differential Context-Dependent Effects of FOG-1 on Mast Cell Development and Differentiation
نویسندگان
چکیده
Department of Stem Cell Pathology, Medical School and Graduate School of Frontier Biosciences; Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Japan Running title: EFFECTS OF FOG-1 ON MAST CELL DIFFERENTIATION Scientific section designations: HEMATOPOIESIS Address correspondence to Toru Nakano Department of Stem cell pathology, Medical School, Osaka University 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan Tel: +81-6-6879-3720; Fax: +81-6-6879-3729 E-mail: [email protected]
منابع مشابه
Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation.
Friend of GATA-1 (FOG-1) is a binding partner of GATA-1, a zinc finger transcription factor with crucial roles in erythroid, megakaryocytic, and mast-cell differentiation. FOG-1 is indispensable for the function of GATA-1 during erythro/megakaryopoiesis, but FOG-1 is not expressed in mast cells. Here, we analyzed the role of FOG-1 in mast-cell differentiation using a combined experimental syste...
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The development of naive CD4+ T cells into a T helper (Th) 2 subset capable of producing interleukin (IL)-4, IL-5, and IL-13 involves a signal transducer and activator of transcription (Stat)6-dependent induction of GATA-3 expression, followed by Stat6-independent GATA-3 autoactivation. The friend of GATA (FOG)-1 protein regulates GATA transcription factor activity in several stages of hematopo...
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The zinc finger transcription factor GATA-1 requires direct physical interaction with the cofactor friend of GATA-1 (FOG-1) for its essential role in erythroid and megakaryocytic development. We show that in the mast cell lineage, GATA-1 functions completely independent of FOG proteins. Moreover, we demonstrate that FOG-1 antagonizes the fate choice of multipotential progenitor cells for the ma...
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